This simple cheek swab test covers an extensive 111 genes, and 129 SNP’s across:
- Cardiovascular Health
- Metabolism & Weight Management
- Emotional & Psychological Wellbeing
- Nutrition & Gut Health
- Food Intolerances
- Drug Metabolism
- Musculoskeletal stability
Your genes are the blueprint for your body's functions. However, environmental factors — including diet, exercise, and exposure to toxins — can modify gene expression, influencing your health positively or negatively. By understanding and optimising these factors, you can enhance your body's performance and overall well-being.
View a sample report here.
Find Out Your Unique DNA Profile
Through this test, you'll gain insights into how your genetics influence critical aspects of your health, including heart function, weight management, mental wellbeing, nutrient absorption, and drug metabolism. You’ll receive a personalised report highlighting how your DNA impacts your overall wellness, along with practical recommendations tailored to your results.
Unlike generic DNA tests, our myDNA Comprehensive Check is conducted by an Australian NATA-accredited laboratory. Results are analysed by our expert team of molecular biologists, data scientists, and clinicians to provide a report that is scientifically accurate and highly actionable. Whether you're looking to optimise your health or manage specific concerns, this test is your guide to unlocking your genetic potential.
What we test
myDNA Genes Covered
The following genes are included within the scope of this test report:
Apolipoprotein E (APOE) is a lipid binding protein that transports triglycerides and cholesterol in multiple tissues, including the brain. There is research to suggest that the APOE-e4 allele has the strongest risk factor gene for Alzheimer’s disease since over 60% of persons with Alzheimer’s disease harbor at least one e4 allele. The e4/e4 genotype is cited as being a higher risk than e3/e4. However, inheriting a single or double ApoE4 genotype does not mean a person will develop the disease as there are many other epigenetic factors at play.
Apolipoprotein E (APOE) is a lipid binding protein that transports triglycerides and cholesterol in multiple tissues, including the brain. There is research to suggest that the APOE-e4 allele has the strongest risk factor gene for Alzheimer’s disease since over 60% of persons with Alzheimer’s disease harbor at least one e4 allele. The e4/e4 genotype is cited as being a higher risk than e3/e4. However, inheriting a single or double ApoE4 genotype does not mean a person will develop the disease as there are many other epigenetic factors at play.
Celiac disease is an immune reaction to eating gluten, a protein found in wheat,barley and rye. Published research shows that approximately 30 percent of the general population have variants in the celiac disease risk genes HLA-DQA1 through HLA-DQB, yet only 3% of these individuals develop celiac disease.
Celiac disease is an immune reaction to eating gluten, a protein found in wheat,barley and rye. Published research shows that approximately 30 percent of the general population have variants in the celiac disease risk genes HLA-DQA1 through HLA-DQB, yet only 3% of these individuals develop celiac disease.
There is research to suggest that mutations in the HFE C282Y may lead to an iron overload due to increased iron absorption and disrupted metabolism. Individuals who carry two copies of the HFE C282Y gene mutation, known as homozygotes, represent the majority (85 to 90 percent) of individuals with hemochromatosis. Whilst those with only one mutation in the HFE C282Y gene are associated with a lower risk of iron overload you may want to consider talking to your doctor about further testing if hemochromatosis runs in your family and have either of these mutations.
MTHFR helps our bodies use folate effectively, but certain genetic differences, like the mutations C677T and A1298C, can slow it down. If someone has two copies of C677T mutation or a mix of one C677T and one A1298C mutation, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.
MTHFR helps our bodies use folate effectively, but certain genetic differences, like C677T and A1298C, can slow it down. If someone has two copies of C677T or a mix of C677T and A1298C, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.
The V158M mutation in COMT can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline, which affects mood, thinking, and stress. This contributes to health outcomes including cognitive performance, susceptibility to psychiatric disorders, and stress-related conditions.
The PEMT C744G mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.
The PEMT M175V mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.
This variant affects alcohol metabolism by reducing ALDH2 enzyme activity. Carriers of the A allele accumulate acetaldehyde, causing flushing, nausea, and higher risks of alcohol-related health issues.
MTHFD1 helps convert one form of folate into another form that is critical for making DNA and RNA, as well as for providing methyl groups for important cellular processes like methylation. Mutations in MTHFD1 result in lower levels of active folate, which is a key input for downstream biological pathways.
MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.
MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.
The TCN2 gene encodes a protein called transcobalamin II, which plays a crucial role in transporting vitamin B12 (cobalamin) in the bloodstream. Homozygous mutations in the TCN2 C766G gene can impact the function of transcobalamin II and subsequently affect the transport of vitamin B12.
Transcobalamin II binds to vitamin B12 in the blood, forming a complex that allows vitamin B12 to be carried to cells throughout the body. Once inside the cells, vitamin B12 is released from transcobalamin II and can be used for various biochemical reactions, including DNA synthesis, nerve function, and red blood cell production.
CYP1A2 is responsible for metabolizing caffeine, a stimulant found in coffee, tea, and other beverages. Variations in the CYP1A2 gene can influence the rate at which caffeine is metabolized, affecting its duration of action and potential impact on sleep. Slow metabolizers of caffeine may experience prolonged stimulation, leading to difficulties falling asleep or maintaining sleep.
The SHBG gene codes for a protein called sex hormone-binding globulin, which plays a key role in regulating the levels of sex hormones like estrogen and testosterone in the body. Genetic variations in the SHBG gene can influence how much SHBG is produced.
Some variations may lead to higher levels of SHBG, which could result in lower levels of free testosterone in the blood. This might contribute to menopausal symptoms, such as hot flashes, mood swings, and decreased libido. On the other hand, certain genetic variants may cause lower levels of SHBG, potentially leading to higher levels of free testosterone. This could impact menopausal women differently, possibly affecting bone health, muscle mass, and overall well-being.
Cardiovascular Health
Cardiovascular health refers to the overall well-being of the heart and blood vessels. Conditions such as cardiovascular disease (CVD), including artery blockage (atherosclerosis), are characterised by the buildup of fatty deposits, cholesterol, and other substances on the walls of arteries. This process narrows and hardens the arteries, reducing blood flow to vital organs and increasing the risk of heart attack, stroke, and other complications. Contributing factors to poor cardiovascular health include high levels of LDL cholesterol, elevated triglycerides, chronic inflammation, high blood pressure, smoking, and insulin resistance.
Metabolic Health & Weight Management
Metabolic health and weight management encompass the body’s ability to efficiently convert food into energy while maintaining a healthy balance of hormones, blood sugar, and lipid levels. Common metabolic conditions include type 2 diabetes, hypothyroidism, liver disease, and obesity, all of which are linked to an increased risk of cardiovascular disease and other chronic illnesses. Poor metabolic health can result in weight gain, fatigue, and difficulty maintaining energy balance. Key contributors include a sedentary lifestyle, poor diet, hormonal imbalances, and chronic inflammation.
Nutrition & Gut Health
Genes such as HLA, PEMT, MTR, and LCT can dictate how your body handles specific foods, potentially leading to conditions like lactose intolerance, inflammatory bowel disease, and IBS (irritable bowel syndrome). Genetic variations such as VDR, PEMT, and MTR can also lead to vitamin deficiencies or malabsorption issues, impacting your overall well-being. These imbalances can cause digestive discomfort, nutrient absorption, and inflammation. The myDNA Comprehensive Check can help pinpoint these variations, guiding you to make smarter dietary choices.
Psychological & Emotional Wellbeing
Emotional and psychological health is controlled by neurotransmitters, hormones, and neural networks in the brain, which regulate mood, stress, and emotional responses. Genetic factors and clinical biomarkers can impact neurotransmitter and hormone levels contributing to problems like anxiety, depression and stress. The PEMT gene affects brain health, while the COMT gene influences the breakdown of dopamine, affecting mood and cognitive function. Variants in these genes can lead to mood swings, anxiety, and other emotional challenges. The myDNA Comprehensive Check can help you understand these genetic factors, guiding you toward optimal mental and emotional well-being.
Cognitive Function
Cognitive function relies on neural connections and the interplay of neurotransmitters, hormones, and other brain chemicals. These elements influence stress responses, mental alertness, focus, motivation, memory, learning, and problem-solving. Factors such as genetic variations (e.g. in the PEMT, COMT, and APOE genes), elevated homocysteine levels, vitamin B12 deficiency, poor sleep, lack of exercise, and chronic stress can negatively impact cognitive performance. The myDNA Comprehensive Check identifies genetic predispositions in these areas, aiding in assessing risks for cognitive decline and chronic inflammation.
Stability & Strength
Strength, stability, and athletic performance rely on the coordinated function of muscles, joints, and bones to support movement and endurance. Bone health plays a crucial role in this balance, as strong bones provide the necessary framework for muscle attachment and joint stability. Weak bones, due to conditions like osteoporosis or low bone density, can increase the risk of fractures and limit physical performance. Similarly, muscle weakness, joint instability, or poor flexibility can compromise overall stability and performance.
Immune Health & Inflammation
Immune health plays a vital role in protecting the body from infections and maintaining overall balance, while inflammation is the body’s natural response to injury or illness. However, chronic inflammation and immune dysregulation can lead to the development of inflammatory and autoimmune conditions, such as rheumatoid arthritis, lupus, or inflammatory bowel disease. These conditions arise when the immune system mistakenly attacks healthy tissues, causing persistent pain, fatigue, and other health complications.
Hormone & Reproductive Health
Hormone & Reproductive Health refers to the balance of hormones that regulate the reproductive system, influencing fertility, menstrual cycles, and overall reproductive function. Hormonal imbalances, such as irregular levels of oestrogen, progesterone, or testosterone, can lead to conditions like infertility, polycystic ovary syndrome (PCOS), and endometriosis. Maintaining hormone balance through lifestyle changes, nutrition, stress management, and, if necessary, medical intervention can support reproductive health and fertility.
Test instructions
Your test kit and all instructions are posted directly to you, and there is no need to visit a collection centre.
Mail your sample back to the lab according to the instructions provided with your kit
Results for this test available in 21-24 business days from being received at the lab and will be published in your online dashboard.
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