This simple cheek swab test covers an extensive 111 genes, and 129 SNP’s across:
- Cardiovascular Health
- Metabolism & Weight Management
- Emotional & Psychological Wellbeing
- Nutrition & Gut Health
- Food Intolerances
- Drug Metabolism
- Musculoskeletal stability
Your genes are the blueprint for your body's functions. However, environmental factors — including diet, exercise, and exposure to toxins — can modify gene expression, influencing your health positively or negatively. By understanding and optimising these factors, you can enhance your body's performance and overall well-being.
View a sample report here.
Find Out Your Unique DNA Profile
Through this test, you'll gain insights into how your genetics influence critical aspects of your health, including heart function, weight management, mental wellbeing, nutrient absorption, and drug metabolism. You’ll receive a personalised report highlighting how your DNA impacts your overall wellness, along with practical recommendations tailored to your results.
Unlike generic DNA tests, our myDNA Comprehensive Check is conducted by an Australian NATA-accredited laboratory. Results are analysed by our expert team of molecular biologists, data scientists, and clinicians to provide a report that is scientifically accurate and highly actionable. Whether you're looking to optimise your health or manage specific concerns, this test is your guide to unlocking your genetic potential.
What we test
myDNA Genes Covered
The following genes are included within the scope of this test report:
Apolipoprotein E (APOE) is a lipid binding protein that transports triglycerides and cholesterol in multiple tissues, including the brain. There is research to suggest that the APOE-e4 allele has the strongest risk factor gene for Alzheimer’s disease since over 60% of persons with Alzheimer’s disease harbor at least one e4 allele. The e4/e4 genotype is cited as being a higher risk than e3/e4. However, inheriting a single or double ApoE4 genotype does not mean a person will develop the disease as there are many other epigenetic factors at play.
Apolipoprotein E (APOE) is a lipid binding protein that transports triglycerides and cholesterol in multiple tissues, including the brain. There is research to suggest that the APOE-e4 allele has the strongest risk factor gene for Alzheimer’s disease since over 60% of persons with Alzheimer’s disease harbor at least one e4 allele. The e4/e4 genotype is cited as being a higher risk than e3/e4. However, inheriting a single or double ApoE4 genotype does not mean a person will develop the disease as there are many other epigenetic factors at play.
Celiac disease is an immune reaction to eating gluten, a protein found in wheat,barley and rye. Published research shows that approximately 30 percent of the general population have variants in the celiac disease risk genes HLA-DQA1 through HLA-DQB, yet only 3% of these individuals develop celiac disease.
Celiac disease is an immune reaction to eating gluten, a protein found in wheat,barley and rye. Published research shows that approximately 30 percent of the general population have variants in the celiac disease risk genes HLA-DQA1 through HLA-DQB, yet only 3% of these individuals develop celiac disease.
There is research to suggest that mutations in the HFE C282Y may lead to an iron overload due to increased iron absorption and disrupted metabolism. Individuals who carry two copies of the HFE C282Y gene mutation, known as homozygotes, represent the majority (85 to 90 percent) of individuals with hemochromatosis. Whilst those with only one mutation in the HFE C282Y gene are associated with a lower risk of iron overload you may want to consider talking to your doctor about further testing if hemochromatosis runs in your family and have either of these mutations.
MTHFR helps our bodies use folate effectively, but certain genetic differences, like the mutations C677T and A1298C, can slow it down. If someone has two copies of C677T mutation or a mix of one C677T and one A1298C mutation, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.
MTHFR helps our bodies use folate effectively, but certain genetic differences, like C677T and A1298C, can slow it down. If someone has two copies of C677T or a mix of C677T and A1298C, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.
The LPA I4399M gene variant is a change in the LPA gene that can increase the risk of heart disease by raising levels of a protein called lipoprotein (a), which can lead to the buildup of plaques in arteries.
The PON1 gene encodes paraoxonase 1, an enzyme that protects cells from oxidative damage by attaching to HDL particles. The Q192R mutation alters the enzyme's efficiency, potentially increasing the risk of heart disease and inflammation.
The PPAR-alpha rs1800206 gene variant is a change in the PPARA gene, which helps regulate how the body uses fats for energy. This variant can affect fat metabolism and influence the risk of developing type 2 diabetes and heart disease.
The APOA2 T-265C gene variant has been associated with differences in body mass index (BMI) and food intake, potentially influencing obesity risk and dietary habits.
This ACSL1 variant is associated with fat metabolism and lipid processing. ACSL1 encodes an enzyme critical for activating long-chain fatty acids, a key step in lipid metabolism. Variants may influence how efficiently the body metabolises and stores fats, potentially affecting energy production and fat distribution.
The GPX1 gene encodes glutathione peroxidase 1, an enzyme that protects cells from oxidative damage. This variant can reduce the enzyme's efficiency, increasing the risk of oxidative stress-related conditions like diabetes complications and certain cancers.
The V158M mutation in COMT can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline, which affects mood, thinking, and stress. This contributes to health outcomes including cognitive performance, susceptibility to psychiatric disorders, and stress-related conditions.
The PEMT C744G mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.
The PEMT M175V mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.
The LCT C-13910T gene variant affects the lactase enzyme, which breaks down lactose. This variant is linked to lactose persistence - the ability to digest lactose. The Wild type variant on the other hand, causes lactose intolerance: difficulty digesting lactose and leading to gastrointestinal symptoms like bloating, gas, and diarrhoea.
This variant affects alcohol metabolism by reducing ALDH2 enzyme activity. Carriers of the A allele accumulate acetaldehyde, causing flushing, nausea, and higher risks of alcohol-related health issues.
The VKORC12 G-1639A gene variant affects how the body processes vitamin K, essential for blood clotting and bone health. This variant can also influence the dosage of blood-thinning medications like warfarin, as it impacts the enzyme's activity involved in recycling vitamin K.
The CYP2R1 gene, is responsible for converting vitamin D into its active form in the liver. This variant can influence vitamin D levels in the body, with certain alleles associated with lower vitamin D levels and potential vitamin D insufficiency.
MTHFD1 helps convert one form of folate into another form that is critical for making DNA and RNA, as well as for providing methyl groups for important cellular processes like methylation. Mutations in MTHFD1 result in lower levels of active folate, which is a key input for downstream biological pathways.
MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.
MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.
The FUT2 gene encodes an enzyme that influences blood group antigen secretion and gut bacteria composition. This variant can cause non-secretor status, affecting gut microbiome diversity and increasing susceptibility to infections like norovirus and autoimmune disorders.
The TCN2 gene encodes a protein called transcobalamin II, which plays a crucial role in transporting vitamin B12 (cobalamin) in the bloodstream. Homozygous mutations in the TCN2 C766G gene can impact the function of transcobalamin II and subsequently affect the transport of vitamin B12.
Transcobalamin II binds to vitamin B12 in the blood, forming a complex that allows vitamin B12 to be carried to cells throughout the body. Once inside the cells, vitamin B12 is released from transcobalamin II and can be used for various biochemical reactions, including DNA synthesis, nerve function, and red blood cell production.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The T102C variant can affect responses to psychotropic drugs and is linked to conditions like schizophrenia and depression.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The G-1438A variant can influence receptor expression, affecting the response to antipsychotics and increasing the risk of depression.
The MAO-A gene encodes an enzyme that breaks down neurotransmitters like serotonin, norepinephrine, and dopamine. The R297R variant can affect enzyme activity, potentially increasing susceptibility to psychiatric conditions such as depression and anxiety.
The BDNF gene encodes brain-derived neurotrophic factor, essential for neuron growth and survival. The V66M variant can impair BDNF secretion, leading to memory issues, mood disorders, and an increased risk of neuropsychiatric conditions like depression and schizophrenia.
The NBPF3 gene is associated with the synthesis of a hormone involved in the clearance of vitamin B6 from the body. Variants can lead to lower levels of vitamin B6 in the blood, which is important for neurological function, red blood cell production, and sugar metabolism.
The IL-6 gene encodes the cytokine interleukin-6 (IL-6), which plays a key role in inflammation and immune response. The G-174C variant can lead to higher levels of IL-6 in the blood, increasing the risk of inflammatory conditions.
The TNF-a gene encodes TNF-alpha, a cytokine involved in inflammation and immune response. The G-308A variant may increase TNF-alpha production, raising the risk of inflammatory conditions and cardiovascular diseases.
CYP1A2 is responsible for metabolizing caffeine, a stimulant found in coffee, tea, and other beverages. Variations in the CYP1A2 gene can influence the rate at which caffeine is metabolized, affecting its duration of action and potential impact on sleep. Slow metabolizers of caffeine may experience prolonged stimulation, leading to difficulties falling asleep or maintaining sleep.
The CYP2C9 gene encodes an enzyme involved in the metabolism of various drugs, including warfarin. The A1075C variant (CYP2C93) affects the enzyme's activity, leading to reduced metabolism of warfarin and an increased risk of bleeding in individuals taking the medication.
The CYP2C19 gene encodes an enzyme involved in the metabolism of various drugs. The C-806T variant (CYP2C1917) increases the enzyme's activity, leading to ultra-rapid drug metabolism and potentially affecting the efficacy and safety of medications.
The CYP2D6 gene encodes an enzyme involved in the metabolism of many drugs, including antidepressants and opioids. The C100T variant (CYP2D610) can lead to increased enzyme activity, affecting how individuals respond to medications.
The CYP3A4 gene encodes an enzyme involved in the metabolism of many drugs and toxins. The A-392G variant (CYP3A41B) can increase the enzyme's activity, potentially affecting drug metabolism.
The ADIPOQ gene encodes the protein adiponectin, which helps regulate glucose levels and fatty acid breakdown. The T45G variant can influence adiponectin levels and is associated with insulin resistance and metabolic diseases.
The MTNR1B gene produces a receptor for melatonin, which regulates sleep-wake cycles. Variants in this gene may raise blood sugar levels, increasing type 2 diabetes risk, and can also affect sleep quality, making it harder to fall or stay asleep.
The TCF7L2 gene encodes a transcription factor involved in the Wnt signalling pathway, which plays a role in regulating blood sugar levels. This variant is associated with an increased risk of type 2 diabetes by affecting insulin secretion and glucose metabolism.
The PPARGC1A gene encodes the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which is a master regulator of mitochondrial biogenesis and energy metabolism. The G482S variant is associated with an increased risk of type 2 diabetes and metabolic diseases.
The SHBG gene codes for a protein called sex hormone-binding globulin, which plays a key role in regulating the levels of sex hormones like estrogen and testosterone in the body. Genetic variations in the SHBG gene can influence how much SHBG is produced.
Some variations may lead to higher levels of SHBG, which could result in lower levels of free testosterone in the blood. This might contribute to menopausal symptoms, such as hot flashes, mood swings, and decreased libido. On the other hand, certain genetic variants may cause lower levels of SHBG, potentially leading to higher levels of free testosterone. This could impact menopausal women differently, possibly affecting bone health, muscle mass, and overall well-being.
The SHBG gene produces sex hormone-binding globulin, which regulates sex hormone levels like oestrogen and testosterone. Variations in the SHBG gene can affect SHBG levels, influencing the risk of type 2 diabetes and menopausal symptoms, as well as bone health, muscle mass, and overall well-being.
The ACE1 gene encodes the angiotensin-converting enzyme (ACE), which regulates blood pressure and fluid balance. The rs4343 variant (A2350G) is linked to higher ACE levels with the G allele, potentially impacting blood pressure and cardiovascular risk.
The AGTR1 gene encodes the angiotensin II type 1 receptor, which plays a role in regulating blood pressure and fluid balance. The A1166C variant can increase the risk of hypertension and metabolic syndrome by affecting the receptor's function.
The NOS1 gene encodes neuronal nitric oxide synthase (NOS1), which produces nitric oxide, involved in regulating blood flow and neurotransmission. Variants are associated with an increased risk of developing diabetic nephropathy and an increased likelihood of renal replacement therapy.
The ADRB2 gene encodes the beta-2 adrenergic receptor, which is involved in the body's response to adrenaline and noradrenaline, affecting heart rate, blood pressure, and metabolism. The G16R variant can influence the receptor's function and has been associated with conditions like asthma.
The DIO1 gene converts inactive thyroid hormone (T4) into its active form (T3), which regulates metabolism and energy use. Variants can affect this conversion, potentially altering thyroid hormone levels and metabolic balance.
The VDR gene encodes the vitamin D receptor, which regulates calcium and phosphate levels, affecting bone health and immune function. The FokI variant impacts VDR activity, with the GG variant being more active, potentially influencing vitamin D metabolism and related health outcomes.
The ABCG2 gene encodes a protein that transports substances like drugs and toxins in and out of cells. The Q141K variant reduces this transport, leading to a buildup of uric acid in the blood, increasing the risk of gout and affecting kidney health.
The CYP17A2 gene encodes an enzyme involved in producing steroid hormones like oestrogen and androgens. The T-34C variant can increase the activity of this enzyme, leading to higher levels of these hormones and potentially affecting conditions like hormone-related cancers and metabolic processes.
The GSTM1 gene encodes an enzyme that detoxifies harmful substances like drugs and toxins. The homozygous genotype results in a deleted, non-functional gene, which may increase susceptibility to certain cancers and chemical sensitivities.
Cardiovascular Health
Cardiovascular health refers to the overall well-being of the heart and blood vessels. Conditions such as cardiovascular disease (CVD), including artery blockage (atherosclerosis), are characterised by the buildup of fatty deposits, cholesterol, and other substances on the walls of arteries. This process narrows and hardens the arteries, reducing blood flow to vital organs and increasing the risk of heart attack, stroke, and other complications. Contributing factors to poor cardiovascular health include high levels of LDL cholesterol, elevated triglycerides, chronic inflammation, high blood pressure, smoking, and insulin resistance.
Metabolic Health & Weight Management
Metabolic health and weight management encompass the body’s ability to efficiently convert food into energy while maintaining a healthy balance of hormones, blood sugar, and lipid levels. Common metabolic conditions include type 2 diabetes, hypothyroidism, liver disease, and obesity, all of which are linked to an increased risk of cardiovascular disease and other chronic illnesses. Poor metabolic health can result in weight gain, fatigue, and difficulty maintaining energy balance. Key contributors include a sedentary lifestyle, poor diet, hormonal imbalances, and chronic inflammation.
Nutrition & Gut Health
Genes such as HLA, PEMT, MTR, and LCT can dictate how your body handles specific foods, potentially leading to conditions like lactose intolerance, inflammatory bowel disease, and IBS (irritable bowel syndrome). Genetic variations such as VDR, PEMT, and MTR can also lead to vitamin deficiencies or malabsorption issues, impacting your overall well-being. These imbalances can cause digestive discomfort, nutrient absorption, and inflammation. The myDNA Comprehensive Check can help pinpoint these variations, guiding you to make smarter dietary choices.
Psychological & Emotional Wellbeing
Emotional and psychological health is controlled by neurotransmitters, hormones, and neural networks in the brain, which regulate mood, stress, and emotional responses. Genetic factors and clinical biomarkers can impact neurotransmitter and hormone levels contributing to problems like anxiety, depression and stress. The PEMT gene affects brain health, while the COMT gene influences the breakdown of dopamine, affecting mood and cognitive function. Variants in these genes can lead to mood swings, anxiety, and other emotional challenges. The myDNA Comprehensive Check can help you understand these genetic factors, guiding you toward optimal mental and emotional well-being.
Cognitive Function
Cognitive function relies on neural connections and the interplay of neurotransmitters, hormones, and other brain chemicals. These elements influence stress responses, mental alertness, focus, motivation, memory, learning, and problem-solving. Factors such as genetic variations (e.g. in the PEMT, COMT, and APOE genes), elevated homocysteine levels, vitamin B12 deficiency, poor sleep, lack of exercise, and chronic stress can negatively impact cognitive performance. The myDNA Comprehensive Check identifies genetic predispositions in these areas, aiding in assessing risks for cognitive decline and chronic inflammation.
Stability & Strength
Strength, stability, and athletic performance rely on the coordinated function of muscles, joints, and bones to support movement and endurance. Bone health plays a crucial role in this balance, as strong bones provide the necessary framework for muscle attachment and joint stability. Weak bones, due to conditions like osteoporosis or low bone density, can increase the risk of fractures and limit physical performance. Similarly, muscle weakness, joint instability, or poor flexibility can compromise overall stability and performance.
Immune Health & Inflammation
Immune health plays a vital role in protecting the body from infections and maintaining overall balance, while inflammation is the body’s natural response to injury or illness. However, chronic inflammation and immune dysregulation can lead to the development of inflammatory and autoimmune conditions, such as rheumatoid arthritis, lupus, or inflammatory bowel disease. These conditions arise when the immune system mistakenly attacks healthy tissues, causing persistent pain, fatigue, and other health complications.
Hormone & Reproductive Health
Hormone & Reproductive Health refers to the balance of hormones that regulate the reproductive system, influencing fertility, menstrual cycles, and overall reproductive function. Hormonal imbalances, such as irregular levels of oestrogen, progesterone, or testosterone, can lead to conditions like infertility, polycystic ovary syndrome (PCOS), and endometriosis. Maintaining hormone balance through lifestyle changes, nutrition, stress management, and, if necessary, medical intervention can support reproductive health and fertility.
Test instructions
Your test kit and all instructions are posted directly to you, and there is no need to visit a collection centre.
Mail your sample back to the lab according to the instructions provided with your kit
Results for this test available in 21-24 business days from being received at the lab and will be published in your online dashboard.
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