Genetic Methylation Check

We assess your body's unique methylation profile based on the genes below. A methylation profile evaluates your body's ability to regulate methylation, a vital process affecting DNA repair, detoxification, neurotransmitter balance, and cardiovascular health. Imbalances can result in undermethylation - linked to high histamine, detox challenges, depression, gastrointestinal issues like leaky gut, inflammatory bowel disease (IBD), food sensitivities, and immune dysfunctions like frequent infections and autoimmune conditions. Overmethylation, on the other hand, is associated with low histamine, anxiety, and mood instability. Poor methylation may also elevate homocysteine, increasing cardiovascular risk, and contribute to impaired cognitive function, fatigue, and neurological problems such as brain fog and memory issues.

Methylation plays a key role in cardiovascular health by regulating processes essential for heart and blood vessel function. Homocysteine, a byproduct with no useful role in the body, is inflammatory and increases the risk of heart attack and stroke. Methylation defects (MTHFR, MTR, MTRR) or nutrient deficiencies can raise blood homocysteine levels, affecting heart and vessel health, and in rare cases, CBS hereditary mutations can raise both blood and urine levels, driving whole-body inflammation. Methylation also helps produce nitric oxide, which relaxes blood vessels to improve blood flow, supports fat metabolism, repairs cardiovascular cells, and controls gene activity, which can prevent or trigger cancer. We analyse your genes to identify weaknesses in these pathways that may impact your heart health.

Methylation is essential for brain health - methylation affects neurotransmitter production, brain cell repair, and inflammation regulation, all of which influence cognitive performance. This test reveals predispositions to elevated homocysteine levels, which are linked to brain inflammation, oxidative stress, and an increased risk of neurodegenerative diseases. Methylation also plays a role in repairing brain cell DNA and maintaining cell membrane health, processes that are vital for cognitive resilience and sharpness. The test can highlight genetic inefficiencies in these areas, helping you understand your risk factors for cognitive decline or chronic inflammation.

Methylation is essential for producing and balancing neurotransmitters like dopamine, serotonin, and noradrenaline, which regulate mood, memory, and focus. We analyse variations in your methylation genes, such as COMT or MTHFR, that may affect these pathways, leading to imbalances associated with anxiety, depression, or brain fog. Based on genetic findings, interventions such as optimised intake of B vitamins, methylated folate, or dietary changes can be suggested to support neurotransmitter balance and brain health.

Your gut health is absolutely crucial and deeply linked with your brain, cardiovascular system, hormones, and immune health. Methylation plays a vital role in maintaining gut health, influencing the integrity of your gut lining, the balance of your gut microbiome, the absorption of essential nutrients, and your liver’s detoxification efficiency. Genetic variations can significantly impact these processes, leading to potential imbalances and health issues. Even without genetic mutations, an imbalanced gut microbiome or a damaged gut lining can severely affect nutrient absorption, compromising methylation and other essential bodily functions. Understanding these connections can guide you towards dietary and lifestyle choices that optimise not just your gut health, but your overall well-being.

Methylation is crucial for energy production as it influences the function of mitochondria, the cell's powerhouses. We analyse your DNA to look for genetic variations that could impair your mitochondrial function, potentially leading to reduced energy production and fatigue. Methylation also plays a vital role in detoxification processes, particularly in the liver - genetic variations affecting methylation can compromise the liver's ability to efficiently eliminate toxins, leading to their accumulation and potential health issues.

Methylation plays a crucial role in controlling gene expression, including those involved in immune response and cellular repair. Abnormal methylation patterns can disrupt immune regulation, causing the body to attack its own tissues and contributing to autoimmune diseases. Additionally, improper methylation can activate oncogenes, increasing the risk of cancer, and reduce the body’s ability to combat oxidative stress, leading to inflammation and tissue damage. Identifying genetic variations that affect methylation helps assess your predisposition to inflammatory, autoimmune, and oxidative stress-related conditions.